Cross-reactivity and 1.4-A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family.

Structural and Functional Studies of Malassezia Sympodialis-derived Allergens

Atopic eczema (AE) is a chronic inflammatory skin disease characterised by pruritic (itchy) skin lesions. The pathogenic mechanisms underlying AE are still unclear, although several factors such as genetic predisposition, a dysfunctional skin barrier, exposure to environmental allergens and skin colonisation with microorganisms appear to be of importance. Malassezia sympodialis is a yeast which...

Genomic Insights into the Atopic Eczema-Associated Skin Commensal Yeast Malassezia sympodialis

UNLABELLED Malassezia commensal yeasts are associated with a number of skin disorders, such as atopic eczema/dermatitis and dandruff, and they also can cause systemic infections. Here we describe the 7.67-Mbp genome of Malassezia sympodialis, a species associated with atopic eczema, and contrast its genome repertoire with that of Malassezia globosa, associated with dandruff, as well as those of...

The Role of Malassezia Allergens and Mast Cells in Atopic Eczema

Atopic eczema (AE) is a chronic inflammatory skin disease, characterized by intense itching, dry skin, infiltration of immune cells and skin lesions. To date, the cause of AE, a disease affecting 15-30% of children and 210% of adults, remains unknown and the pathomechanisms are not fully understood. Many factors, however, have been implied to contribute to this complex disorder, such as genetic...

The Effects of the Allergen Mala s 11, from the Opportunistic Yeast Malassezia, on Antigen Presenting Cells

Neurobiology of Disease -Internexin Is Structurally and Functionally Associated with the Neurofilament Triplet Proteins in the Mature CNS

Aidong Yuan,1,3 Mala V. Rao,1,3 Takahiro Sasaki,1 Yuanxin Chen,1,2 Asok Kumar,1,3 Veeranna,1,3 Ronald K. H. Liem,5 Joel Eyer,6 Alan C. Peterson,7 Jean-Pierre Julien,8 and Ralph A. Nixon1,3,4 1Center for Dementia Research and 2Department of Medical Physics, Nathan Kline Institute, Orangeburg, New York 10962, Departments of 3Psychiatry and 4Cell Biology, New York University School of Medicine, Ne...